ABSTRACT
Abstract Background Telogen effluvium is the most common form of non-scarring alopecia characterized by diffuse hair loss. Ischemia-modified albumin is a marker of oxidative stress and inflammation. Objective The aim of this study was to compare the levels of ischemia-modified albumin of telogen effluvium patients with healthy controls. Methods Ninety-one patients diagnosed with telogen effluvium and 35 healthy volunteers were included in the study. Serum ischemia-modified albumin level was determined by a fast-colorimetric method, and albumin cobalt binding test. The results were evaluated statistically. Results There was no statistically significant difference between the serum albumin values of patient and control groups (p = 0.739). Serum ischemia-modified albumin values were significantly higher in the patients with telogen effluvium than healthy controls (p < 0.001). Study limitations Body mass index values of the patient and control groups could not be calculated. Conclusions To the best of the authors' knowledge, this is the first clinical study to investigate the role of oxidative stress in the pathogenesis of telogen effluvium using ischemia-modified albumin as a biomarker. Based on the results of the present study, it can be considered that oxidative stress plays an important role in the pathogenesis of telogen effluvium. There is a need for further studies to support the results of this study, to demonstrate the possible effects of oxidative stress, and to investigate the other oxidative stress markers in the pathogenesis of telogen effluvium.
Subject(s)
Humans , Male , Female , Serum Albumin , Oxidative Stress/physiology , Alopecia Areata , Biomarkers , Environmental Biomarkers , AlopeciaABSTRACT
Aloe barbadensis is the most widely used both commercially and therapeutic properties. It has been used for an array of ailments since ancient times as a medicinal plant. There are more than 360 different species of Aloe. Its products have been used in health foods for medical and preservative purposes. The objective of this study was to search the effects of Aloe barbadensis on the rat's placenta. Gel form of Aloe barbadensis is used in the study. It is commercial, preserved but otherwise untreated form of Aloe Barbadensis gel capsul. Female Wistar Albino rats were divided into three groups. Placenta specimens from each groups were processed for the microscopic examination. Trophoblastic giant cells and spongiotrophoblasts were decreased in number after Aloe barbadensis: trophoblastic giant cells which showed degenerative changes. The nuclei of these giant cells were going degeneration characterized by pyknosis and bizarrely shaped. Extracellular matrix production around the cells was increased, thicker and more irregular basal membrane like formation around the cells. Decreased and ab normal vessel formation in labyrinth área was clear and reduced functional capacity of the trophoblastic barier. The study shows that, in the presence of Aloe barbadensis, relevant alterations associated with a possible compensatory adjustment to maintain adequate metabolic exchange take place in the structure of placenta. Our results also demonstrated that the exposure to Aloe barbadensis during pregnancy not led to fetal growth retardation, fetal death, abortion or teratogenic effect.
Aloe barbadensis es ampliamente utilizada comercialmente, debido a sus propiedades terapéuticas. Desde la antigüedad, se ha utilizado como planta medicinal para combatir una variedad de enfermedades. Hay más de 360 especies diferentes de Aloe. Sus productos han sido utilizados en los alimentos saludables para propósitos médicos y preventivos. El objetivo de este estudio fue buscar los efectos del Aloe barbadensis en la placenta de la rata. Se utilizó gel de Aloe barbadensis en el estudio. Su presentación comercial, cápsulas de gel de Aloe barbadensis de uso preventivo, no de tratamiento. Ratas Wistar albinas hembras se dividieron en tres grupos. Las placentas de cada uno de los especímenes de los grupos fueron procesadas para el examen microscópico. Las células gigantes trofoblásticas y los espongioblastos disminuyeron de número después de ser expuestas aAloe barbadensis; las células trofoblásticas gigantes mostraron cambios degenerativos. Los núcleos de estas células gigantes se caracterizaron por la degeneración, mostrando picnosis y forma extraña. La producción de matriz extracelular alrededor de las células se incrementó, hubo engrosamiento y formación de una membrana basal más irregular alrededor de las células. La disminución y formación de vasos anormales en la zona del laberinto eran evidentes y además hubo reducción de la capacidad funcional de la barrera trofoblástica. El estudio mostró que, en presencia de Aloe barbadensis, las alteraciones asociadas con un posible ajuste compensatorio paraman tener un nivel adecuado de intercambio metabólico, tienen lugar en la estructura de la placenta. Nuestros resultados también demostraron que la exposición al Aloe barbadensis durante el embarazo no produjo retraso del crecimiento fetal, muerte fetal, aborto ni efecto teratogénico.